Citation
Gl. Phillips et al., Granulocyte-colony stimulating factor (G-CSF)-primed, delayed marrow harvests as a source of hematopoietic stem and progenitor cells for allogeneic transplantation, LEUK LYMPH, 35(3-4), 1999, pp. 303-309
Citations number
24
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194
→ ACNP
Volume
35
Issue
3-4
Year of publication
1999
Pages
303 - 309
Database
ISI
SICI code
1042-8194(199910)35:3-4<303:GSF(DM>2.0.ZU;2-E
Abstract
We evaluated the ability of G-CSF to increase the number of hematopoietic s
tem cells obtained by "delayed" BM harvest for allogeneic transplantation.
Five normal donors received G-CSF @ 10mcg/kg/day x 5 followed by repeat PB
and BM assays at day 6 and 16, and BM harvest at day 16. Stem cells were no
t increased in the BM at day 16. Five patients underwent BMT and engrafted
at +10 to +19 days. While the tested strategy offers no intrinsic advantage
s, its potential cannot be evaluated fully without alternative timing and/o
r additional, "early acting" growth factors.