The importance of transcription factors in the regulation of inflammatory response in polytraumatized patients

The authors have investigated the relationship between selenium and transcr iption factors (NF-kappa B and AP-1) in the field of pathogenesis of polytr auma. Correlations between plasma selenium content and transcription factor binding activity have been found. The measured connecting capacitances of transcription factors have been associated with the severity of disease. To harden the results of this research a randomized double blind study with sodium selenite substitution is necessary next. This study will be to esta blish the therapy with sodium selenite in the treatment of polytrauma.