Spontaneous improvement of optic pathway lesions in children with neurofibromatosis type 1

Two cases of spontaneous improvement of optic pathway lesions in neurofibro matosis type 1 are reported. At time of diagnosis the children were aged 21 and 32 months respectively; they have been followed by both MRI and clinic al evaluation for 5 and 4 years. MRI findings of the first 19 months of fol low-up for Case 1 have been described by us before. On MRI serial evaluatio n, Case 1 showed an almost complete normalization of the size of lesions an d a resolution of enhancement, whereas Case 2 showed a slight decrease in t he size of lesions and a resolution of enhancement. From the clinical point of view Case 1 showed a normalization of his clinical signs, whereas in Ca se 2, a visual improvement was only slight, if at all present, In Case 1, t he clinical improvement seemed to follow the spontaneous regression of the lesions detected by MRI.