K. Hayakawa et al., Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol - in vitro explant study, NEUROSCI L, 274(2), 1999, pp. 103-106
We examined the preventive effects of nerve growth factor (NGF) against neu
rotoxicity induced in aged rats by anticancer drugs such as cisplatin, vinc
ristine and taxol using a superior cervical ganglion explant culture system
. The inhibition of neurite outgrowth by cisplatin, vincristine and taxol w
as markedly prevented by co-treatment with NGF. The neurite and nerve cell
populations were well preserved in vincristine and taxol, whereas cisplatin
reduced these populations as compared with control even when treated with
NGF. These results indicate that, just as in young adult rats, NGF prevents
toxic sympathetic nerve injury induced by vincristine and taxol even in ag
ed rats, but dose not protect against cisplatin-induced nerve cell injury.
(C) 1999 Elsevier Science ireland Ltd. All rights reserved.