Clustering of the group III metabotropic glutamate receptor 4a at parallelfiber synaptic terminals in the rat cerebellar molecular layer

Authors
Mateos, JM Elezgarai, I Benitez, R Osorio, A Bilbao, A Azkue, JJ Kuhn, R Knopfel, T Grandes, P
Citation
Jm. Mateos et al., Clustering of the group III metabotropic glutamate receptor 4a at parallelfiber synaptic terminals in the rat cerebellar molecular layer, NEUROSCI RE, 35(1), 1999, pp. 71-74
Citations number
26
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE RESEARCH
ISSN journal
01680102 → ACNP
Volume
35
Issue
1
Year of publication
1999
Pages
71 - 74
Database
ISI
SICI code
0168-0102(199910)35:1<71:COTGIM>2.0.ZU;2-L
Abstract
We report in this study with a pre-embedding immunogold method, the cluster ing of the group III metabotropic glutamate receptor 4a (mGluR4a) along the presynaptic membrane of parallel fiber synaptic terminals in the cerebella r molecular layer. The mGluR4a clusters were homogeneously distributed and interspaced by about 60 nm. These results suggest a particular arrangement of mGluR4a which might help to a rapid and effective activation of this rec eptor by glutamate. (C) 1999 Elsevier Science Ireland Ltd. All rights reser ved.