We discuss the measurements of deuterium abundances in high redshift quasar
absorbers, in the solar system and in the interstellar medium. We present
new results that indicate spatial variations of the deuterium abundance in
the interstellar medium at the level of similar to 50% over scales possibly
as small as similar to 10 pc, and discuss plausible causes for the origin
of these variations. (C) 1999 Elsevier Science B.V. All rights reserved.