Effects of 4-methylsterols from algae and of beta sitosterol on cholesterol metabolism in rats

Citation
D. Kritchevsky et al., Effects of 4-methylsterols from algae and of beta sitosterol on cholesterol metabolism in rats, NUTR RES, 19(11), 1999, pp. 1649-1654
Citations number
11
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
NUTRITION RESEARCH
ISSN journal
02715317 → ACNP
Volume
19
Issue
11
Year of publication
1999
Pages
1649 - 1654
Database
ISI
SICI code
0271-5317(199911)19:11<1649:EO4FAA>2.0.ZU;2-Q
Abstract
Male Sprague Dawley rats (8/gp) were fed one of the following diets: AIN76A (C), C plus 0.5% 4-methylsterols (CM), C plus 0.5% beta sitosterol (CS), C plus 0.5% cholesterol (CC), CC plus 0.15% sodium deoxycholate (CB), CB plu s 1% 4-methylsterols (CBM) or CB plus 1% beta sitosterol (CBS). The 4-methy lsterols had no adverse effect on weight gain or organ weight. The 4-methyl sterols did not affect serum or liver lipids when added to the control diet or to the cholesterol-bile salt diet. When added to the control diet beta sitosterol increased the percentage of serum HDL cholesterol and lowered le vels of liver esterified cholesterol. When added to the cholesterol-bile sa lt diet beta sitosterol significantly lowered serum cholesterol and raised HDL-cholesterol levels; beta sitosterol also reduced liver total cholestero l. (C) 1999 Elsevier Science Inc.