Clinical and therapeutic properties of Cushing's disease in childhood

Gushing's disease (CD) in adolescence and childhood is a rare pathology and has some different clinical and therapeutic characteristics than in adults . We report 3 cases treated surgically, with the diagnosis of CD, Their com mon complaints were short stature and obesity. Endocrinological investigati ons and radiological evaluation pointed out the diagnosis of CD for all chi ldren. They were operated on by the transsphenoidal route, and adenoma rese ction was performed. Histopathologic and immunohistochemical examination of the tissue specimens confirmed the diagnosis of CD, Long-term follow-up de monstrated weight loss and increase in height.