Therapeutic targets for hypoxia-elicited pathways

Diminished oxygen supply to tissues (hypoxia) can stem from many sources, a nd is a contributing factor to diverse disease processes. Cell and tissue r esponses to hypoxia are diverse and include dramatic changes in metabolic d emand, regulation of cellular gene products, and release of lipid and prote in mediators. Surprisingly little attention has been paid to targeted devel opment of therapeutics for hypoxia-related disease processes. This review w ill focus on recent advances in cellular and molecular biology pertaining t o the hypoxia response, and will discuss paradigms used to study hypoxia an d the potential targets for therapeutic intervention.