Synthetic approaches to biologically active bisphosphonates and phosphonocarboxylates

Authors
McKenna, CE Kashemirov, BA Li, ZM
Citation
Ce. Mckenna et al., Synthetic approaches to biologically active bisphosphonates and phosphonocarboxylates, PHOSPHOR SU, 146, 1999, pp. 313-316
Citations number
14
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
146
Year of publication
1999
Pages
313 - 316
Database
ISI
SICI code
1042-6507(1999)146:<313:SATBAB>2.0.ZU;2-K
Abstract
Some current and potential therapeutic uses of bisphosphonates and phosphon ocarboxylates are summarized. The feasibility of synthesizing alpha-hydroxy alpha-alkyl/aryl methyl-enebisphosphonates via Grignard addition to tetraa lkyl carbonylbisphosphonates 6 is demonstrated, and a new synthesis of 6 un der very mild conditions is described.