The design and synthesis of sulfur containing bisphosphonic acids for the treatment of arthritis

Authors
Almstead, NG Dansereau, SM Francis, MD Snider, CM Ebetino, FH
Citation
Ng. Almstead et al., The design and synthesis of sulfur containing bisphosphonic acids for the treatment of arthritis, PHOSPHOR SU, 146, 1999, pp. 325-328
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
146
Year of publication
1999
Pages
325 - 328
Database
ISI
SICI code
1042-6507(1999)146:<325:TDASOS>2.0.ZU;2-J
Abstract
The sulfur containing bisphosphonic acids have been examined as a chondropr otective therapy for the treatment of arthritis. Several compounds have dem onstrated both in vitro and in vivo activity. The newly synthesized compoun ds all contain a latent or a free thiol group which may bind to the zinc at om in the active site of the matrix metalloproteases. The in vivo activity of some of these bisphosphonic acids in the rat adjuvant model of arthritis is also discussed.