Chemistry of oligonucleotide-gold nanoparticle conjugates

Authors
Letsinger, RL Mirkin, CA Elghanian, R Mucic, RC Storhoff, JJ
Citation
Rl. Letsinger et al., Chemistry of oligonucleotide-gold nanoparticle conjugates, PHOSPHOR SU, 146, 1999, pp. 359-362
Citations number
13
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
146
Year of publication
1999
Pages
359 - 362
Database
ISI
SICI code
1042-6507(1999)146:<359:COONC>2.0.ZU;2-1
Abstract
Conjugates prepared by immobilizing thiol-terminated oligonucleotides onto gold nanoparticles form stable colloidal solutions in aqueous media. The ol igonucleotides can serve as linkers to organize the gold particles reversib ly into three dimensional assemblies, and the gold particles can function a s colorimetric reporters for hybridization of the bound oligomers with targ et oligonucleotides in solution.