Bifunctional chelation systems based on hydroxymethyl phosphine-based donor groups

Authors
Volkert, WA Karra, SR Gali, H Schibli, R Katti, KV
Citation
Wa. Volkert et al., Bifunctional chelation systems based on hydroxymethyl phosphine-based donor groups, PHOSPHOR SU, 146, 1999, pp. 489-492
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
146
Year of publication
1999
Pages
489 - 492
Database
ISI
SICI code
1042-6507(1999)146:<489:BCSBOH>2.0.ZU;2-9
Abstract
Chelating frameworks based on hydroxymethylene phosphine (HMP) functionalit ies provides a novel approach to produce chelate-conjugates compatible with development of new Tc-99m and Re-186/188 radiopharmaceuticals. Studies wit h a bombesin conjugate demonstrates the potential of using HMP-based chelat ing frameworks to develop radiolabeled receptor-avid agents for targeting c ancers.