J. Florian et A. Warshel, Quantum-chemical insights into mechanisms of the nonenzymatic hydrolysis of phosphate monoesters, PHOSPHOR SU, 146, 1999, pp. 525-528
Citations number
17
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
The interpretation of a large number of experiments that are generally cons
idered to support the dissociative or metaphosphate mechanism of phosphate
monoesters in aqueous solution is scrutinized using results of ab initio qu
antum chemical calculations. It is concluded that while it is currently not
clear whether the associative or dissociative mechanism of phosphate monoe
ster hydrolysis is operating in aqueous solution, the associative transitio
n state can be better stabilized by the interaction between the equatorial
oxygens and the proton donor groups in the enzyme active sites.