The synthesis of novel modified nucleic acid monomers and their subsequentsolid phase oligomerisation to give 3 '-methylene phosphonate DNA (3MP)

Authors
Collingwood, SP Douglas, ME Natt, F Pieles, U
Citation
Sp. Collingwood et al., The synthesis of novel modified nucleic acid monomers and their subsequentsolid phase oligomerisation to give 3 '-methylene phosphonate DNA (3MP), PHOSPHOR SU, 146, 1999, pp. 645-648
Citations number
6
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
146
Year of publication
1999
Pages
645 - 648
Database
ISI
SICI code
1042-6507(1999)146:<645:TSONMN>2.0.ZU;2-K
Abstract
A protected hypophosphorus acid synthon allowed selective monoalkylation of hypophosphorus acid with 3'-iodo-methylene thymidine. The resulting H-phos phonous acid was an effective monomer for the solid phase synthesis of 3MP DNA which displayed strong binding to complementary RNA.