Pregnancy outcome in HIV-infected women.

Objective. To identify the medical complications in a cohort of HIV-infecte d, pregnant women and to determine the risk of having the virus in the deve lopment of these complications. Material and methods. A cohort study of 44 HIV-infected and 88 seronegative pregnant women was performed. Pregnancy wa s followed and perinatal results were compared. HIV-infected women were asy mptomatic with CD4 count > 200 mm(3). Patients were matched for age and soc ioeconomic status. Results. in 42 (95.4%) of HIV patients the disease had b een transmitted sexually; 35 (79.5%) had been infected for less than one ye ar and 15 (34%) received antiviral treatment during pregnancy. HIV-infected patients showed greater risk of infectious disorders (RR3.1, C195% 1.9-52) , cervical infections (RR 2.2, C195% 1-48) and sexually transmitted disease s (RR 18,C195% 2.3-137). Newborns showed low birth weight and were prematur e, and neonatal affections were similar in the two groups compared. Stratif ied analysis showed that no antiretroviral treatment and more than three se xual partners increase the risk of infections. Conclusions. HIV-seropositiv e, asymptomatic, pregnant women with > 200/mm(3) CD4 count did not show gre ater medical risk along pregnancy and birth, although higher incidence of i nfections was detected.