Rc. Pattinson, A meta-analysis of the use of corticosteroids in pregnancies complicated by preterm premature rupture of membranes, S AFR MED J, 89(8), 1999, pp. 870-873
A systematic review of the literature has been undertaken with regard to th
e use of corticosteroids in women with preterm premature rupture of membran
es (PPROM). The benefit of corticosteroids clearly outweighs their potentia
l harmful effects. Antibodies should probably be induced in any management
protocol for women with PPROM. There is no reason to suggest that use of co
rticosteroids in women with PPROM needs to be restricted in developing coun
tries.