Tutorial in biostatistics genetic mapping of complex traits

Statistical genetic mapping methods are powerful tools for finding genes th at contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in th ose mechanisms to locate, with increasing precision, trait genes on the hum an genome. We provide an overview of the two major classes of mapping metho ds, genetic linkage analysis and linkage disequilibrium analysis, and relat ed concepts of genetic inheritance. Copyright (C) 1999 John Wiley & Sons, L td.