E. Baloglu et al., Preparation and release characteristics of tolmetin sodium matrix tablets with ethylene maleic acid anhydrides, STP PHARM S, 9(4), 1999, pp. 329-334
The aim of this study is to prepare the sustained release formulation of to
lmetin sodium with different particle sizes containing varying types and pe
rcentages of ethylene maleic anhydride resins. The dissolution tests were a
pplied and the dissolution kinetics of formulas were obtained. It was seen
that the formulations provided sustained release and particle size of drug
and the type and the concentration of ethylene maleic anhydride resins affe
cted the dissolution rate.