Synthesis of two novel 2-aminocyclopropylidene-1,1-bisphosphonates

Authors
Couthon, H Gourves, JP Guervenou, J Corbel, B Sturtz, G
Citation
H. Couthon et al., Synthesis of two novel 2-aminocyclopropylidene-1,1-bisphosphonates, SYN COMMUN, 29(23), 1999, pp. 4251-4260
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
23
Year of publication
1999
Pages
4251 - 4260
Database
ISI
SICI code
0039-7911(1999)29:23<4251:SOTN2>2.0.ZU;2-C
Abstract
The synthesis of tetraethyl aminocyclopropylidene-1,1-bisphosphonate 1 and tetraethyl 2-(aminomethyl)cyclopropylidene-1,1-bisphosphonate 2 are describ ed. The key steps include Michael addition, cyclisation and Curtius reactio n for compound 1 and cyclisation, azide nucleophilic substitution and Staud inger reaction for 2.