NMR recognition studies of C center dot G base pairs by new easily accessible heterobicyclic systems

Authors
Lecubin, F Benhida, R Fourrey, JL Sun, JS
Citation
F. Lecubin et al., NMR recognition studies of C center dot G base pairs by new easily accessible heterobicyclic systems, TETRAHEDR L, 40(46), 1999, pp. 8085-8088
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
46
Year of publication
1999
Pages
8085 - 8088
Database
ISI
SICI code
0040-4039(19991112)40:46<8085:NRSOCC>2.0.ZU;2-M
Abstract
Recognition of DNA duplexes by tripler forming oligonucleotides (TFO) is li mited to DNA homopurine sequences. As a first step to overcome this limitat ion we report here NMR recognition studies of the C . G base pair by new he terocyclic systems, derived from benzimidazole and benzoxazole units bearin g an urea donor moiety, designed to bound to the 4-amino group of the cytos ine and the O4- and N7-atoms of the guanosine bases, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.