Synthesis and stability study of the new pentammonio lipid pcTG90, a gene transfer agent

Authors
Nazih, A Cordier, Y Bischoff, R Kolbe, HVJ Heissler, D
Citation
A. Nazih et al., Synthesis and stability study of the new pentammonio lipid pcTG90, a gene transfer agent, TETRAHEDR L, 40(46), 1999, pp. 8089-8091
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
46
Year of publication
1999
Pages
8089 - 8091
Database
ISI
SICI code
0040-4039(19991112)40:46<8089:SASSOT>2.0.ZU;2-Q
Abstract
The cationic lipid pcTG90 has been prepared from (S)-1-aminopropane-2,3-dio l by N-acylation with N-protected 18-amino-3,7,11,15-tetraazaoctadecanoic a cid and O-acylation with oleic acid. The former acid could be obtained from 1,3-propanediamine via tetraprotected caldopentamine. The stability of the cationic lipid in HEPES buffer has been studied. (C) 1999 Elsevier Science Ltd. All rights reserved.