The asymmetric addition of trimethylsilyl cyanide to ketones catalysed by a bimetallic, chiral (salen)titanium complex

Authors
Belokon, YN Green, B Ikonnikov, NS North, M Tararov, VI
Citation
Yn. Belokon et al., The asymmetric addition of trimethylsilyl cyanide to ketones catalysed by a bimetallic, chiral (salen)titanium complex, TETRAHEDR L, 40(46), 1999, pp. 8147-8150
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
46
Year of publication
1999
Pages
8147 - 8150
Database
ISI
SICI code
0040-4039(19991112)40:46<8147:TAAOTC>2.0.ZU;2-3
Abstract
The use of a bimetallic titanium salen complex as a catalyst for the asymme tric addition of trimethylsilylcyanide to ketones is reported. The cyanohyd rin trimethylsilyl ethers are obtained with enantiomeric excesses of up to 72% from reactions carried out at room temperature and atmospheric pressure employing 0.5 mol% of the catalyst. (C) 1999 Elsevier Science Ltd. All rig hts reserved.