Circulating antibodies and antigens correlate with egg counts in human fascioliasis

We explored the relationships between specific Ige antibody levels and circ ulating E/S antigen to intensity of Fasciola infection in the human host. T wenty patients with patent infection and six healthy individuals were enrol led in the study Intensity of infection was determined by repeated egg coun ts in stools, while IgG antibodies against adult Fasciola gigantica somatic FI, FII and against EIS antigens were measured as ELISA O.D. readings. The level of circulating E/S antigens was determined by IELISA. Positivity as well as levels of antibodies and antigen correlated with infection intensit y. These findings may disclose in the future a relation between morbidity i n the acute phase and worm load.