Cutaneous lesions with histopathologic evidence of metabolic epidermal necr
osis in the dog are commonly associated with a significant derangement in h
epatic function and occasionally associated with abnormalities in endocrine
pancreatic function such as a glucagon-secreting tumor. Hyperglycemia or f
rank diabetes mellitus is a common finding in both the hepatocutaneous synd
rome and the glucagonoma syndrome. The long-term prognosis for dogs with he
patocutaneous syndrome is poor, while the prognosis for dogs with a localiz
ed pancreatic tumor may be favorable only if postoperative complications ar
e minimal.