Metabolic epidermal necrosis-hepatocutaneous syndrome

Cutaneous lesions with histopathologic evidence of metabolic epidermal necr osis in the dog are commonly associated with a significant derangement in h epatic function and occasionally associated with abnormalities in endocrine pancreatic function such as a glucagon-secreting tumor. Hyperglycemia or f rank diabetes mellitus is a common finding in both the hepatocutaneous synd rome and the glucagonoma syndrome. The long-term prognosis for dogs with he patocutaneous syndrome is poor, while the prognosis for dogs with a localiz ed pancreatic tumor may be favorable only if postoperative complications ar e minimal.