Studies on calcium modulatory activities of 2,6,6-trimethyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives

Twenty-two new 2,6,6-trimethyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroq uinoline derivatives (compounds 1-22) have been prepared. The structures of the compounds were characterised by IR, H-1-NMR, mass spectroscopy and ele mental analyses. The calcium antagonistic activities of the compounds were determined by the tests performed on isolated rabbit ileum and lamb carotid artery. According to the isolated rabbit ileum activity tests the most act ive compounds an 10 and 12 and according to the lamb carotid activity tests the most active compounds are 6 and 10.