Anti-inflammatory activity of 2-acyl-5(3)-hydroxytetrahydro-1H-pyrazole derivatives

The anti-inflammatory effects of five pyrazolidine derivatives on white mic e and laboratory rats were studied using models of thermal aseptic inflamma tion and inflammation induced by injection of carragenin and histamine, as well as models of ,,cotton-ball granuloma" and epinephrine (adrenaline)-ind uced pulmonary edema. These effects were compared with those of the most co mmonly used non-steroid anti-inflammatory drugs: such as phenylbutazone (CA S 50-33-9) and diclofenac (CAS 15307-79-6). It was found that the pyrazolid ine compounds studied induced a pronounced anti-inflammatory effect by inhi biting both the proliferative and exudative phases of inflammation. At the same time, as compared to natural nonsteroid anti-inflammatory drugs, these compounds had a lower toxicity and induced neither gastric ulcers nor supp ression of hemopoiesis.