Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that ca talyzes intermembrane transfer of phosphatidylcholines in vitro. We have cl oned a cDNA encoding the human ortholog of PC-TP and have determined its ti ssue-specific expression as well al; genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-bas ed single strand conformation polymorphism analysis of an interspecific bac kcross assigned mouse Pctp to the region of syntenic conservation on chromo some 11. (C) 1999 Elsevier Science B.V. All rights reserved.