Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3

Authors
Bailey, MES Albrecht, BE Johnson, KJ Darlison, MG
Citation
Mes. Bailey et al., Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3, BBA-GENE ST, 1447(2-3), 1999, pp. 307-312
Citations number
19
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1447
Issue
2-3
Year of publication
1999
Pages
307 - 312
Database
ISI
SICI code
0167-4781(19991028)1447:2-3<307:GLARHM>2.0.ZU;2-G
Abstract
GABA(C) receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: p1 (GABRR1), p2 (GABRR2) and p3 (GABRR3). We show that GABRR1 and GABRR2 are located close together, in a region of chro mosome 6q that contains loci for inherited disorders of the eye, but that G ABRR3 maps to chromosome 3q11-q3.3. Our mapping data suggest that the p pol ypeptide genes, which are thought to share a common ancestor with GABAA rec eptor subunit genes, diverged at an early stage in the evolution of this ge ne family. (C) 1999 Elsevier Science B.V. All rights reserved.