At the nexus between pattern formation and cell-type specification: the generation of individual neuroblast fates in the Drosophila embryonic centralnervous system
Jb. Skeath, At the nexus between pattern formation and cell-type specification: the generation of individual neuroblast fates in the Drosophila embryonic centralnervous system, BIOESSAYS, 21(11), 1999, pp. 922-931
The specification of specific and often unique fates to individual cells as
a function of their position within a developing organism is a fundamental
process during the development of multicellular organisms. The development
of the Drosophila embryonic central nervous system serves as an excellent
model system in which to clarify the developmental mechanisms that link pat
tern formation to cell-type specification. The Drosophila embryonic central
nervous system develops from a set of neural stem cells termed neuroblasts
. Neuroblasts arise from the ectoderm in an invariant pattern, and each neu
roblast acquires a unique fate based on its position within this pattern. T
wo groups of genes recently have been demonstrated to govern the individual
fate specification of neuroblasts. One group, the segment polarity genes,
enables neuroblasts that develop in different anteroposterior positions to
acquire different fates. The second group, referred to as the columnar gene
s, ensures that neuroblasts that develop in different dorsoventral domains
assume different fates. When integrated, the activities of the segment pola
rity and columnar genes create a Cartesian coordinate system that bestows u
nique fates to individual neuroblasts as a function of their position of fo
rmation within the ectoderm. BioEssays 1999;21:922-931. (C) 1999 John Wiley
& Sons, Inc.