Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis
D. Berg et al., Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis, BL COAG FIB, 10(7), 1999, pp. 435-438
Chronic Fatigue and/or Fibromyalgia have long been diseases without definit
ion. An explanatory model of coagulation activation has been demonstrated t
hrough use of the ISAC panel of five tests, including, Fibrinogen, Prothrom
bin Fragment 1+2, Thrombin/AntiThrombin Complexes, Soluble Fibrin Monomer,
and Platelet Activation by flow cytometry. These tests show low level coagu
lation activation from immunoglobulins (Igs) as demonstrated by Anti-B(2)GP
I antibodies, which allows classification of these diseases as a type of an
tiphospholipid antibody syndrome. The ISAC panel allows testing for diagnos
is as well as monitoring for anticoagulation protocols in these patients. (
C) 1999 Lippincott Williams & Wilkins.