Synthesis of racemic brevioxime

Citation
Dlj. Clive et S. Hisaindee, Synthesis of racemic brevioxime, CHEM COMMUN, (22), 1999, pp. 2251-2252
Citations number
21
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
22
Year of publication
1999
Pages
2251 - 2252
Database
ISI
SICI code
1359-7345(1999):22<2251:SORB>2.0.ZU;2-K
Abstract
Amine hydrochloride 12 and beta-keto thioester 16 were coupled and treated with TFA; the resulting alcohols 18 were oxidized and converted into a mixt ure of oximes 20, from which the major product, racemic brevioxime 1, was i solated.