Equine protozoal myeloencephalitis (EPM) may be one of the most difficult a
ntemortem diagnoses for practitioners to make accurately. Much of this diff
iculty results from the perceived clinical variability in the presentation
of EPM. Because antemortem laboratory testing for EPM is only one piece of
the diagnostic puzzle, diagnostic accuracy relies on the completeness of ph
ysical, neurologic, and diagnostic evaluations.