R. Jorde et al., Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromso study, EUR J ENDOC, 141(4), 1999, pp. 350-357
Objective: To study associations between serum ionised calcium, serum parat
hyroid hormone (PTH) and blood pressure.
Design: A population based, cross-sectional study was used,
Methods: Blood pressure, body mass index, serum ionised calcium and serum P
TH were measured in 460 males and 486 females in the Tromso study in 1994/1
995. None were on medication for hypertension. The data were analysed with
a multiple Linear regression model.
Results: When looking at subjects with serum ionised calcium <1.39 mmol/l,
there was a significant negative association (P < 0.01) between serum ionis
ed calcium and PTH, There was no association between blood pressure and ser
um ionised calcium, in both sexes there was a significant positive associat
ion between age and serum PTH (P < 0.01). For women, but not for men, there
was a significant positive association between serum PTH and systolic and
diastolic blood pressure (P < 0.01). Within each age group there was a diff
erence in both systolic and diastolic blood pressure of 3-10 mm Hg between
the upper and lower serum PTH halves of the female population. Females with
hypertension had significantly higher serum PTH levels than the normotensi
ve females (P < 0.01).
Conclusion: Serum PTH is strongly and positively associated with blood pres
sure in women.