What is the real role of CD40 in cancer immunotherapy?

Authors
Costello, RT Gastaut, JA Olive, D
Citation
Rt. Costello et al., What is the real role of CD40 in cancer immunotherapy?, IMMUNOL TOD, 20(11), 1999, pp. 488-493
Citations number
60
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
11
Year of publication
1999
Pages
488 - 493
Database
ISI
SICI code
0167-5699(199911)20:11<488:WITRRO>2.0.ZU;2-Z
Abstract
The CD40-CD40 ligand (CD40L) system is of pivotal importance in the immune response via interactions between T cells and antigen-presenting cells. Rec ent reports have demonstrated that CD40 triggering improves tumour immunoge nicity. Nonetheless, as discussed here, the implications of the CD40-CD40L system in host-tumour interactions are pleiotropic and should be evaluated carefully before targeting CD40 for antitumour strategies.