T cells orchestrate intestinal mucosal shape and integrity

Authors
MacDonald, TT Bajaj-Elliott, M Pender, SLF
Citation
Tt. Macdonald et al., T cells orchestrate intestinal mucosal shape and integrity, IMMUNOL TOD, 20(11), 1999, pp. 505-510
Citations number
44
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
11
Year of publication
1999
Pages
505 - 510
Database
ISI
SICI code
0167-5699(199911)20:11<505:TCOIMS>2.0.ZU;2-X
Abstract
T helper I-type immune reactions in the gut cause important human diseases, such as Crohn's disease and coeliac disease. Here, Tom MacDonald, Mona Ell iott and Sylvia Pender suggest that the tissue injury in these diseases is mediated not by the immune cells, but by cytokine-induced changes in kerati nocyte growth fact or and matrix metalloproteinase production by resident g ut myofibroblasts.