High-performance liquid chromatography study of the enantiomer separation of chrysanthemic acid and its analogous compounds on a terguride-based stationary phase

The direct enantioseparation of chrysanthemic acid [2,2-dimethyl-3-(2-methy lpropenyl)-cyclopropanecarboxylic acid] and its halogen-substituted analogu es was systematically studied by HPLC using a terguride-based chiral statio nary phase in combination with a UV diode array and chiroptical detectors. Isomers with (1R) configuration always eluted before those with (IS) config uration. The elution sequence of cis- and trans-isomers was strongly affect ed by mobile phase pH, whereas the enantioselectivity remained the same. Co nditions for the separation of all the enantiomers were also examined. This method was used for monitor the hydrolytic degradation products of Cyfluth rin (Baythroid) in soil under laboratory conditions. (C) 1999 Elsevier Scie nce B.V. All rights reserved.