High-performance liquid chromatography study of the enantiomer separation of chrysanthemic acid and its analogous compounds on a terguride-based stationary phase
M. Dondi et al., High-performance liquid chromatography study of the enantiomer separation of chrysanthemic acid and its analogous compounds on a terguride-based stationary phase, J CHROMAT A, 859(2), 1999, pp. 133-142
The direct enantioseparation of chrysanthemic acid [2,2-dimethyl-3-(2-methy
lpropenyl)-cyclopropanecarboxylic acid] and its halogen-substituted analogu
es was systematically studied by HPLC using a terguride-based chiral statio
nary phase in combination with a UV diode array and chiroptical detectors.
Isomers with (1R) configuration always eluted before those with (IS) config
uration. The elution sequence of cis- and trans-isomers was strongly affect
ed by mobile phase pH, whereas the enantioselectivity remained the same. Co
nditions for the separation of all the enantiomers were also examined. This
method was used for monitor the hydrolytic degradation products of Cyfluth
rin (Baythroid) in soil under laboratory conditions. (C) 1999 Elsevier Scie
nce B.V. All rights reserved.