Bispecific antibodies in cancer therapy, from the laboratory to the clinic

Bispecific monoclonal antibodies (BiMAb) have been shown to be able to cont ribute to an immunological approach in cancer therapy. In this review, esse ntial aspects regarding the production of BiMAb and modes to apply them in immunotherapy for cancer are discussed. The pros and cons of BiMAb are cons idered, and the development from application in animal models to clinical s tudies is reviewed. The most important clinical trials are summarized, and the different problems encountered are discussed. Provided some crucial pro blems can be overcome, BiMAb will have a place in the treatment of cancer, especially in the setting of minimal residual disease.