Cat scratch disease (CSD) is a common infectious cause of subacute regional
lymphadenopathy. Bartonella henselae is the principal etiologic agent. Abo
ut 10% of CSD patients experience atypical manifestations, including rashes
. The most common cutaneous manifestation of CSD is a papule at the inocula
tion site. We report a case of CSD presenting with an eruption on the upper
trunk, reminiscent of Sweet's syndrome, accompanied by lymphadenopathy, ar
thralgia, and fever. Response to systemic corticosteroids was remarkable. H
istopathologic findings refuted the diagnosis of Sweet's syndrome. Identifi
cation of anti-B henselae antibodies and B henselae DNA in the affected lym
ph node confirmed the diagnosis of CSD. This is a first report of extensive
papuloedematous eruption as a cutaneous manifestation of CSD. Accurate dia
gnosis is possible due to the availability of serological tests and DNA amp
lification techniques.