We report a case of extragenital bowenoid papulosis (BP) in a healthy immun
ocompetent 42-year-old man. The lesions occurred on the anterolateral aspec
ts of the neck and were not associated with genital, oral, or periungual le
sions. Lesional skin tested positive with the Digene hybrid capture system
cocktail assay that identifies infection with a mixture of high to intermed
iate oncogenic human papillomavirus (HPV) types, including types 16, 18, 31
, 33, 35, 45, 51, 52, and 56. This cocktail assay identifies infection with
HPV types typically associated with high-grade squamous intraepithelial le
sions and invasive carcinoma. This case represents the sixth case of isolat
ed cutaneous BP occurring a significant distance from the genital region.