Successful Therapy with an Anticholinesterase Agent: Post-poliomyelitis syn
drome (PPS) is characterised by the appearance of new neuromuscular symptom
s decades after recovery from paralytic poliomyelitis. We describe a thirty
-seven-year old Korean lady who suffered from poliomyelitis with transitory
tetraparesis in the first year of her life. A permanent atrophic paresis o
f her right leg remained. Before admittance the paresis of the right leg in
creased progressively. Additionally, muscle fatigue and pain on exertion in
the other extremities and generalised fatigue occurred. Physical examinati
on including repetitive muscular contraction revealed a myasthenic syndrome
of non-paretic muscles. Single-fiber electromyography of nonparetic muscle
s showed increased jitter indicating a neuromuscular junction transmission
defect. Both myasthenic syndrome and pathological jitter improved under the
rapy with low-dose pyridostigmine. The pathogenesis of PPS is discussed in
the light of the clinical findings, successful therapy with pyridostigmine,
and current literature.