Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic

Authors
Peruzzi, L Gianoglio, B Porcellini, MG Coppo, R
Citation
L. Peruzzi et al., Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic, LANCET, 354(9190), 1999, pp. 1615-1615
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
354
Issue
9190
Year of publication
1999
Pages
1615 - 1615
Database
ISI
SICI code
0140-6736(19991106)354:9190<1615:NERFAW>2.0.ZU;2-D
Abstract
Cyclo-oxygenase-type-2 (COX-2) enzyme is fundamental for nephrogenesis, upr egulated on fetal membranes and myometrium at parturition. Fetal COX-2 inhi bition, due to maternal nimesulide assumption, can be responsible for neona tal chronic renal failure.