Expression of the highly conserved RNA binding protein KOC in embryogenesis

The human KOC gene which is highly expressed in cancer shows typical struct ural features of an RNA binding protein. We analyzed the temporal and spati al expression pattern of KOC in mouse embryos at different gestational ages . The expression of KOC seems to be ubiquitous at early stages. During adva nced gestation highest KOC expression occurs in the gut, pancreas, kidney, and in the developing brain. The expression pattern of KOC was compared to its Xenopus homologue Vg1-RBP during frog development. Similar expression w as found in these organs suggesting an important functional role of the hom ologous proteins in embryonic development. (C) 1999 Elsevier Science Irelan d Ltd. AII rights reserved.