F. Thomke et al., Spontaneous intracranial hypotension. Clinical, neuroradiological, cisternographic, and cerebrospinal fluid findings, NERVENARZT, 70(10), 1999, pp. 909-915
We report 11 patients with orthostatic headache due to spontaneous intracra
nial hypotension. Nausea (3 patients) and abducens palsy (2 patients) were
the main additional symptoms. Ten patients had CSF pleocytosis (6 to 43 whi
te cells/mu l) and/or increased protein (581 to 1668 mg/l). CT and/or MRI d
ocumented bifrontal accentuated subdural hygromas and hematomas in 5 patien
ts. MRI also documented diffuse meningeal gadolinium enhancement in all 4 p
atients examined, and descent of the brain in one. Cisternography was done
in 9 patients and revealed a decreased or absent activity over the convexit
ies and early detection of the tracer in the bladder in all, and a CSF leak
at the cervicothoracal junction in 2 patients. Most patients improved with
bed rest, increased fluid intake (oral or intravenous),steroids, and/or ep
idural blood patch. Subdural hematomas increased in 2 patients and have to
be drained. Spontaneous intracranial hypotension is due to a CSF leak follo
wed by decreased CSF volume and hydrostatic CSF pressure changes. The locat
ions of the tea ks are mainly cervical or at the cervicothoracal junction.
MRI always documents diffuse meningeal gadolinium enhancement. Treatment of
choice is an epidural blood patch. Surgical treatment may be needed in pat
ients with subdural hematomas or meningeal diverticula. Prognosis is typica
lly good, but subdural hematomas may occasionally lead to an increased intr
acranial pressure.