This paper summarizes by four recent examples the procedure of the characte
rization of groups at risk for ingestion of food chemicals and its limitati
ons. The examples concern two food additives (sulfites and aspartame), one
nutrient (calcium), and one food contaminant (patuline). On the one hand, r
esults show that the empirical description of a group at risk is nowadays t
he best way to provide to risk managers information useful for consumer pro
tection. On the other hand, these examples show that in any case if risk 0
does not exist, it is impossible to completely avoid any group at risk. The
responsibility of risk managers is to decide what is the minimum size of t
he population to protect as a function of the risk and of the cost of the p
rotection.