Prediction of accelerated progression of chronic glomerulonephritis basingon clinical and histomorphological data

Aim. To find our predictive value of three factors in progression of chroni c glomerulonephritis (CGN): unfavorable clinical course, unfavorable morpho logical type and tubulointerstitial changes. Materials and methods. 150 CGN patients entered the trial. Frequency of ons et of chronic renal failure (CRF) within 7 years after the diagnosis was ch osen as a criterium of accelerated progression of CGN (AP CGN). Chi-square criterium was used for testing relationships between AP CGN and the paramet ers under study. Results. The findings support previously published data on statistically mo re frequent occurrence of AP CGN in unfavorable clinical types (active neph ritic and nephrotically-hypertensive), in unfavorable morphological types ( mesangiocapillary CGN and focal-segmental hyalinosis/sclerosis and tubuloin terstitial lesions). In unfavorable clinical types there was a significantl y more frequent occurrence of AP CGN irrespective of unfavorable morphologi cal changes. In contrast, both in unfavorable and favorable clinical types, frequency of AP CGN in unfavorable morphological types of CGN and tubuloin terstital changes ions the same. Conclusion, Clinical type of CGN is a valuable prognostic criterium for AP CGN.