Detection of urate tubulointerstitial nephritis: Contribution of the diagnostic questionnaire

Aim. To develop a diagnostic questionnaire to identify individuals with uri c acid hyperproduction and risk of urate tubulointerstitial nephritis (UTIN ). Materials and methods. Clinical symptoms of 650 patients with verified hype ruricemia or hyperuricosemia have been summarized to design a special quest ionnaire which will be able to identify subjects to whom test for uricemia and uricosuria may be recommended to prevent onset and/or progression of UT IN. Results. The questionnaire has been compiled which has rather high sensitiv ity and specificity in identification of persons with hyperuricemia and/or hyperuricosuria at risk to develop UTIN. Conclusion. The designed questionnaire allows to select subjects with exist ing UTIN or at UTIN risk both in population and individual studies.