Prostaglandin phosphonic acids through homolytic halodecarboxylation of prostaglandins F-1 alpha and F-2 alpha

Authors
Kende, AS Milbank, JBJ Ebetino, FH deLong, MA
Citation
As. Kende et al., Prostaglandin phosphonic acids through homolytic halodecarboxylation of prostaglandins F-1 alpha and F-2 alpha, TETRAHEDR L, 40(47), 1999, pp. 8189-8192
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
47
Year of publication
1999
Pages
8189 - 8192
Database
ISI
SICI code
0040-4039(19991119)40:47<8189:PPATHH>2.0.ZU;2-H
Abstract
Phosphonic acid derivatives of prostaglandins F-1 alpha and F-2 alpha were prepared through Arbuzov reaction of 2-decarboxy-2-iodoprostaglandin interm ediates. The intermediate iodo compounds, which are potentially valuable fo r the synthesis of other analogs, were obtained from the parent prostagland ins by Barton's modification of the Hunsdiecker reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.