Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: A cost effective strategy for prevention of cytomegalovirus disease inadult liver transplant recipients
S. Kusne et al., Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: A cost effective strategy for prevention of cytomegalovirus disease inadult liver transplant recipients, TRANSPLANT, 68(8), 1999, pp. 1125-1131
Background The aim of the study was to assess the incidence of cytomegalovi
rus (CMV) infection and disease in adult liver transplant recipients, using
routine preemptive therapy guided by the pp65 antigenemia test.
Methods. Antigenemia was monitored weekly after liver transplantation (OLTX
) for the first 3 months, and once a month for another 3 months. CMV serone
gative recipients were treated preemptively for the first positive antigene
mia, Seropositive recipients were treated only when their antigenemia count
reached a threshold of greater than or equal to 100 positive cells per 200
,000 leukocytes.
Results. A total of 144 patients were included between June 1994 and April
1995, of which 137 (95%) were primary OLTX, The percentage of positive anti
genemia and CMV disease was 55 and 8%, respectively, Seventy-eight (54%) pa
tients were protocol-monitored for the entire follow-up (group 1) and recei
ved appropriate preemptive therapy, although 66 (46%) patients had protocol
violation by having missed blood samples or blood drawn at unscheduled tim
es (group 2), Using Cox's proportional hazards model, patients with a first
antigenemia count of >11 leukocytes had a significantly higher rate of CMV
disease compared to patients with an antigenemia count less than or equal
to 11 leukocytes (RR=7.3, 95% confidence interval = 2.2 to 24.5), In a mult
ivariate Cox regression analysis, adjustments were made to control for: gro
up 1 versus group 2, use of OKT3, and serology risk categories. This analys
is showed that the relative rate of CMV disease was still significantly hig
her among patients with antigenemia count >11 leukocytes (adjusted RR=4.9,
95% confidence interval=1.3 to 18.1). The estimated cost of preemptive ther
apy was less than that of prophylaxis with i.v. (14-day course) or oral (90
-day course) ganciclovir.
Conclusions. Preemptive therapy guided by pp65 antigenemia is a useful and
cost effective strategy for prevention of CMV disease.