Filippi syndrome: Report of three additional cases

Filippi syndrome is an autosomal recessive condition characterized by varia ble soft tissue syndactyly of the fingers and toes, microcephaly, pre- and postnatal growth retardation, mildly abnormal craniofacial appearance, and mental retardation. We report on three unrelated individuals with Filippi s yndrome. All have microcephaly, minor facial anomalies, variable syndactyly of digits, growth impairment, and developmental delay. One patient also ha s polydactyly, which has not been reported previously in the Filippi syndro me. (C) 1999 Wiley-Liss, Inc.